Abstract 5

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A pilot study was conducted in the first two monkeys using either radiolabeled Dm-Na-P or radiolabeled hydrocortisone sodium succinate together with lidocaine HCI. This study indicated an approximately tenfold increase in the quantity of Dm-Na-P delivered to the test electrodes (4mA;20 minutes) whereas the quantity of hydrocortisone delivered from the test electrodes was only marginally (~10%) increased as compared with that from the controls. In terms of an antiinflammatory activity, the effective dose of Dm-Na-P in al tissue layers underlying the test electrodes was at least tenfold that of the hydrocortisone. Therefore further trials with hydrocortisone were abandoned.

In the second animal, positive test electrodes (5mA; 20 minutes) were sited over five joints on the right side of the body and matching control of electrodes (0mA; 20 minutes) were placed over corresponding joints on the left side of the body. The control and test electrodes each contained 1.omL tritium labeled Dm-Na-P (~4.0mg) and 2.0mL 4% lidocaine HCl (80mg).

Local tissue concentrations of Dm-Na-P were higher than those that would be obtained by systemic therapy and lower than would be obtained by local injection.
RESULTS and DISCUSSION
?...less than 1% of the amount of drug iontophoresed was detected in the blood at the end of the experiment.

?Detectable quantities were found in all layers under all test electrodes down to, and including, tendinous structures and catilaginous tissue.

? The advantages of iontophoresis and the results of these experiments suggest that iontophoresis may be an effacious and desirable method to administer steroids to localized regions of inflammation.
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