Abstract 9

This case was designed to evaluate the effectiveness of dexamethasone iontophoresis alone and with a supervised exercise training program on muscular strength, joint performance and cardiorespiratory endurance in a 37-year old woman with rheumatoid arthritis. Phase one of the treatment (8 weeks) was developed to determine the effectiveness of dexamethasone iontophoresis to the knee joint (3 times each week), with one knee joint receiving the dexamethasone and the other knee receiving a placebo. In phase two (48 weeks) the subject had both knee joints phoresed with dexamethasone and received range of motion exercises (without resistance) to both knee joints. The supervised training program, phase three (12 weeks) consisted of cycle ergometry, low-resistance knee exercise and continued iontophoresis to both knee joints. The subject was assessed before and after each phase. Muscle strength improved in phase I and II with the greatest increase in phase III. Range of motion and swelling improved during all phases. Cardiorespitory endurance improved only in phase III. Further research in this area involving a larger number of patients and a variety of joints is needed to determine the true effectiveness of the regimen.

?The results of this case study indicate that the delivery of dexamethasone iontophoresis combined with a supervised exercise program may be effective for improving muscle strength, joint range of motion, joint swelling and cardiorespitory endurance in a patient with rheumatoid arthritis.

?The use of iontophoresis of small amounts of cartiosteroid targeted for site specific joint delivery may be effective in assisting patients with rheumatoid arthritis in decreasing their overall corticosteroid intake, and thus reduce side effects, like water retention weight gain and myopathy, that may affect function.
Live Chat Software